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Journal of Clinical Microbiology, August 2007, p. 2723-2725, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00015-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Methods To Identify the Klebsiella pneumoniae Carbapenemase in Enterobacteriaceae

Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia

Received 3 January 2007/ Returned for modification 13 February 2007/ Accepted 6 June 2007

The Klebsiella pneumoniae carbapenem (KPC) ß-lactamase occurs in Enterobacteriaceae and can confer resistance to all ß-lactam agents including carbapenems. The enzyme may confer low-level carbapenem resistance, and the failure of susceptibility methods to identify this resistance has been reported. Automated and nonautomated methods for carbapenem susceptibility were evaluated for identification of KPC-mediated resistance. Ertapenem was a more sensitive indicator of KPC resistance than meropenem and imipenem independently of the method used. Carbapenemase production could be confirmed with the modified Hodge test.

Published ahead of print on 20 June 2007.

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