This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, K. F.
Right arrow Articles by Patel, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, K. F.
Right arrow Articles by Patel, J. B.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, August 2007, p. 2723-2725, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00015-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Methods To Identify the Klebsiella pneumoniae Carbapenemase in Enterobacteriaceae{triangledown}

K. F. Anderson,* D. R. Lonsway, J. K. Rasheed, J. Biddle, B. Jensen, L. K. McDougal, R. B. Carey, A. Thompson, S. Stocker, B. Limbago, and J. B. Patel

Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia

Received 3 January 2007/ Returned for modification 13 February 2007/ Accepted 6 June 2007

The Klebsiella pneumoniae carbapenem (KPC) ß-lactamase occurs in Enterobacteriaceae and can confer resistance to all ß-lactam agents including carbapenems. The enzyme may confer low-level carbapenem resistance, and the failure of susceptibility methods to identify this resistance has been reported. Automated and nonautomated methods for carbapenem susceptibility were evaluated for identification of KPC-mediated resistance. Ertapenem was a more sensitive indicator of KPC resistance than meropenem and imipenem independently of the method used. Carbapenemase production could be confirmed with the modified Hodge test.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Mail Stop G-08, 1600 Clifton Road NE, Atlanta, GA 30333. Phone: (404) 639-2824. Fax: (404) 639-1381. E-mail: ebi2{at}cdc.gov

{triangledown} Published ahead of print on 20 June 2007.

Journal of Clinical Microbiology, August 2007, p. 2723-2725, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00015-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Schechner, V., Straus-Robinson, K., Schwartz, D., Pfeffer, I., Tarabeia, J., Moskovich, R., Chmelnitsky, I., Schwaber, M. J., Carmeli, Y., Navon-Venezia, S. (2009). Evaluation of PCR-Based Testing for Surveillance of KPC-Producing Carbapenem-Resistant Members of the Enterobacteriaceae Family. J. Clin. Microbiol. 47: 3261-3265 [Abstract] [Full Text]  
  • Landman, D., Bratu, S., Quale, J. (2009). Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae. J Med Microbiol 58: 1303-1308 [Abstract] [Full Text]  
  • Kitchel, B., Rasheed, J. K., Patel, J. B., Srinivasan, A., Navon-Venezia, S., Carmeli, Y., Brolund, A., Giske, C. G. (2009). Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258. Antimicrob. Agents Chemother. 53: 3365-3370 [Abstract] [Full Text]  
  • Grobner, S., Linke, D., Schutz, W., Fladerer, C., Madlung, J., Autenrieth, I. B., Witte, W., Pfeifer, Y. (2009). Emergence of carbapenem-non-susceptible extended-spectrum {beta}-lactamase-producing Klebsiella pneumoniae isolates at the university hospital of Tubingen, Germany. J Med Microbiol 58: 912-922 [Abstract] [Full Text]  
  • Toye, B., Krajden, S., Fuksa, M., Low, D. E., Pillai, D. R. (2009). Carbapenem resistance in Canada. CMAJ 180: 1225-1226 [Full Text]  
  • Fisher, M. A., Stamper, P. D., Hujer, K. M., Love, Z., Croft, A., Cohen, S., Bonomo, R. A., Carroll, K. C., Petti, C. A. (2009). Performance of the Phoenix bacterial identification system compared with disc diffusion methods for identifying extended-spectrum {beta}-lactamase, AmpC and KPC producers. J Med Microbiol 58: 774-778 [Abstract] [Full Text]  
  • Gootz, T. D., Lescoe, M. K., Dib-Hajj, F., Dougherty, B. A., He, W., Della-Latta, P., Huard, R. C. (2009). Genetic Organization of Transposase Regions Surrounding blaKPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital. Antimicrob. Agents Chemother. 53: 1998-2004 [Abstract] [Full Text]  
  • McGettigan, S. E., Andreacchio, K., Edelstein, P. H. (2009). Specificity of Ertapenem Susceptibility Screening for Detection of Klebsiella pneumoniae Carbapenemases. J. Clin. Microbiol. 47: 785-786 [Abstract] [Full Text]  
  • Endimiani, A., Hujer, A. M., Perez, F., Bethel, C. R., Hujer, K. M., Kroeger, J., Oethinger, M., Paterson, D. L., Adams, M. D., Jacobs, M. R., Diekema, D. J., Hall, G. S., Jenkins, S. G., Rice, L. B., Tenover, F. C., Bonomo, R. A. (2009). Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA. J Antimicrob Chemother 63: 427-437 [Abstract] [Full Text]  
  • Peirano, G., Seki, L. M., Val Passos, V. L., Pinto, M. C. F. G., Guerra, L. R., Asensi, M. D. (2009). Carbapenem-hydrolysing {beta}-lactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil. J Antimicrob Chemother 63: 265-268 [Abstract] [Full Text]  
  • Cole, J. M., Schuetz, A. N., Hill, C. E., Nolte, F. S. (2009). Development and Evaluation of a Real-Time PCR Assay for Detection of Klebsiella pneumoniae Carbapenemase Genes. J. Clin. Microbiol. 47: 322-326 [Abstract] [Full Text]  
  • Tsakris, A., Kristo, I., Poulou, A., Themeli-Digalaki, K., Ikonomidis, A., Petropoulou, D., Pournaras, S., Sofianou, D. (2009). Evaluation of Boronic Acid Disk Tests for Differentiating KPC-Possessing Klebsiella pneumoniae Isolates in the Clinical Laboratory. J. Clin. Microbiol. 47: 362-367 [Abstract] [Full Text]  
  • Bennett, J. W., Herrera, M. L., Lewis, J. S. II, Wickes, B. W., Jorgensen, J. H. (2009). KPC-2-Producing Enterobacter cloacae and Pseudomonas putida Coinfection in a Liver Transplant Recipient. Antimicrob. Agents Chemother. 53: 292-294 [Abstract] [Full Text]  
  • Tsakris, A., Kristo, I., Poulou, A., Markou, F., Ikonomidis, A., Pournaras, S. (2008). First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests. J Antimicrob Chemother 62: 1257-1260 [Abstract] [Full Text]  
  • Doi, Y., Potoski, B. A., Adams-Haduch, J. M., Sidjabat, H. E., Pasculle, A. W., Paterson, D. L. (2008). Simple Disk-Based Method for Detection of Klebsiella pneumoniae Carbapenemase-Type {beta}-Lactamase by Use of a Boronic Acid Compound. J. Clin. Microbiol. 46: 4083-4086 [Abstract] [Full Text]  
  • Petrella, S., Ziental-Gelus, N., Mayer, C., Renard, M., Jarlier, V., Sougakoff, W. (2008). Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A {beta}-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France. Antimicrob. Agents Chemother. 52: 3725-3736 [Abstract] [Full Text]  
  • Hindiyeh, M., Smollen, G., Grossman, Z., Ram, D., Davidson, Y., Mileguir, F., Vax, M., Ben David, D., Tal, I., Rahav, G., Shamiss, A., Mendelson, E., Keller, N. (2008). Rapid Detection of blaKPC Carbapenemase Genes by Real-Time PCR. J. Clin. Microbiol. 46: 2879-2883 [Abstract] [Full Text]  
  • Tibbetts, R., Frye, J. G., Marschall, J., Warren, D., Dunne, W. (2008). Detection of KPC-2 in a Clinical Isolate of Proteus mirabilis and First Reported Description of Carbapenemase Resistance Caused by a KPC {beta}-Lactamase in P. mirabilis. J. Clin. Microbiol. 46: 3080-3083 [Abstract] [Full Text]  
  • Rasheed, J. K., Biddle, J. W., Anderson, K. F., Washer, L., Chenoweth, C., Perrin, J., Newton, D. W., Patel, J. B. (2008). Detection of the Klebsiella pneumoniae Carbapenemase Type 2 Carbapenem-Hydrolyzing Enzyme in Clinical Isolates of Citrobacter freundii and K. oxytoca Carrying a Common Plasmid. J. Clin. Microbiol. 46: 2066-2069 [Abstract] [Full Text]  
  • Aschbacher, R., Doumith, M., Livermore, D. M., Larcher, C., Woodford, N. (2008). Linkage of acquired quinolone resistance (qnrS1) and metallo-{beta}-lactamase (blaVIM-1) genes in multiple species of Enterobacteriaceae from Bolzano, Italy. J Antimicrob Chemother 61: 515-523 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»