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Journal of Clinical Microbiology, August 2007, p. 2740-2742, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.01093-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Contribution of a New Mutation in parE to Quinolone Resistance in Extended-Spectrum-ß-Lactamase-Producing Escherichia coli Isolates{triangledown}

Antonio Sorlozano,1 Jose Gutierrez,1* Antonio Jimenez,2 Juan de Dios Luna,3 and José Luis Martínez2

Departments of Microbiology,1 Biostatistics, School of Medicine, University of Granada,3 Department of Urology, San Cecilio University Hospital, Granada, Spain2

Received 31 May 2007/ Accepted 5 June 2007

Mutations in the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were studied in 30 fluoroquinolone-resistant clinical isolates of Escherichia coli producing extended-spectrum ß-lactamases. Ten isolates showed a mutation in parE that was significantly associated with an increase in the MIC for fluoroquinolones.

* Corresponding author. Mailing address: Departamento de Microbiología, Facultad de Medicina, Avda de Madrid 11, E-18012 Granada, Spain. Phone: 34 958 24 35 50. Fax: 34 958 24 61 19. E-mail: josegf{at}ugr.es

{triangledown} Published ahead of print on 13 June 2007.

Journal of Clinical Microbiology, August 2007, p. 2740-2742, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.01093-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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