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Journal of Clinical Microbiology, January 2008, p. 265-273, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.00937-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Nocardia cyriacigeorgica, an Emerging Pathogen in the United States{triangledown}

Robert Schlaberg,1 Richard C. Huard,1,2 and Phyllis Della-Latta1,2*

Department of Pathology,1 Clinical Microbiology Service, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, New York 100322

Received 4 May 2007/ Returned for modification 17 September 2007/ Accepted 29 October 2007

Nocardia cyriacigeorgica is recognized as an emerging pathogen in many parts of the world. We present the first case description of invasive N. cyriacigeorgica pulmonary infection in the United States identified to the species level by 16S rRNA and hsp65 sequence analysis. A subsequent retrospective molecular screening of recent Nocardia clinical isolates at our New York City medical center yielded an additional six N. cyriacigeorgica isolates. Because routine laboratory algorithms for the phenotypic identification of Nocardia species are limited in practice, the true prevalence of N. cyriacigeorgica infections may be greater than currently appreciated. Indeed, we present evidence confirming that N. cyriacigeorgica is coincident with the unofficial species designation Nocardia asteroides complex antimicrobial susceptibility pattern type VI and distinct from the N. asteroides sensu stricto strain ATCC 19247T. As nocardial species identity can predict antimicrobial susceptibility and guide clinical management, we offer simplified phenotypic and molecular protocols to assist the identification of N. cyriacigeorgica.

* Corresponding author. Mailing address: Clinical Microbiology Service, NewYork-Presbyterian Hospital, Columbia University Medical Center, CHC 3-325, 622 W 168th St., New York, NY 10032. Phone: (212) 305-2929. Fax: (212) 305-8971. E-mail: pd23{at}columbia.edu

{triangledown} Published ahead of print on 14 November 2007.

Journal of Clinical Microbiology, January 2008, p. 265-273, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.00937-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Thrasher, J. D, Crawley, S. (2009). The biocontaminants and complexity of damp indoor spaces: more than what meets the eyes. Toxicol Ind Health 25: 583-615 [Abstract]  
  • Witebsky, F. G., Conville, P. S., Wallace, R. J. Jr., Brown-Elliott, B. A., Huard, R. C., Schlaberg, R., Della-Latta, P. (2008). Nocardia cyriacigeorgica--an Established Rather than an Emerging Pathogen. J. Clin. Microbiol. 46: 2469-2470 [Full Text]  


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