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Journal of Clinical Microbiology, January 2008, p. 377-379, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.00568-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Clinical Impact of a PCR Assay for Rapid Identification of Klebsiella pneumoniae in Blood Cultures{triangledown}

A. Neuberger,1 I. Oren,2 and H. Sprecher3*

Department of Internal Medicine, Rambam Health Care Campus, Haifa, Israel,1 Infectious Disease Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel,2 Laboratory of Clinical Microbiology, Rambam Health Care Campus, Haifa, Israel3

Received 14 March 2007/ Returned for modification 4 June 2007/ Accepted 2 October 2007

The clinical impact of a rapid PCR identification assay for Klebsiella pneumoniae in positive blood cultures was prospectively evaluated. Multivariate analysis identified the rapid PCR assay as the only significant factor in decreasing the time lapse preceding the initiation of appropriate antimicrobial therapy (hazards ratio, 3.03; confidence interval, 1.62 to 5.68; P, 0.001).

* Corresponding author. Mailing address: Clinical Microbiology Laboratory, Rambam Medical Center, P.O. Box 9602, Haifa 31096, Israel. Phone: 972-4-8542876. Fax: 972-4-8542087. Email: h_sprecher{at}rambam.health.gov.il

{triangledown} Published ahead of print on 17 October 2007.

Journal of Clinical Microbiology, January 2008, p. 377-379, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.00568-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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