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Journal of Clinical Microbiology, October 2008, p. 3192-3200, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00628-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Human Enterovirus 71 in the United Kingdom from 1998 to 2006{triangledown}

Jon M. Bible,1 Miren Iturriza-Gomara,2 Brian Megson,2 David Brown,2 Panagiotis Pantelidis,3 Pam Earl,4 Justin Bendig,4 and C. Y. William Tong1,5*

Infection and Immunology Delivery Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom,1 Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, London, United Kingdom,2 Interstitial Lung Disease Group, Department of Population Genetics and Gene Therapy, National Heart and Lung Institute, Imperial College, School of Medicine, London, United Kingdom,3 Department of Medical Microbiology, Epsom and St. Helier University Hospitals, Epsom, Surrey, United Kingdom,4 Department of Infectious Diseases, King's College London School of Medicine, London, United Kingdom5

Received 2 April 2008/ Returned for modification 9 June 2008/ Accepted 11 July 2008

The last decade witnessed a significant increase in epidemic activity of human enterovirus 71 (EV71) in the Western Pacific Region (WPR). In most European countries, this risk is unrecognized despite occasional cases of severe disease and two severe outbreaks in Eastern Europe 30 years ago. In this study we report the first examination of the molecular epidemiology of EV71 in the United Kingdom from 1998 to 2006. Genomic regions encoding the 1D coat protein (VP1) and 3D polymerase (Pol) from 32 EV71 isolates associated with neurological or cutaneous manifestations were sequenced. Phylogenetic analyses of VP1 and 3D Pol sequences identified genotype C as the dominant strain. Several United Kingdom isolates had genetic linkages with predated C1 or C2 strains from Europe and the WPR. Recombination events were not detected between United Kingdom strains. However, a previously published Taiwanese strain was identified as an intergenotypic recombinant. EV71 genotype C appears to have continuous circulation in the United Kingdom from 1998 to 2006 with repeated introductions of new strains replacing previous strains. It is necessary to continuously monitor the molecular evolution and recombination events of EV71.

* Corresponding author. Mailing address: Infection and Immunology Unit, Guys and St Thomas' NHS Foundation Trust, 5th Floor, North Wing, St Thomas' Hospital, London SE1 7EH, United Kingdom. Phone: 207 188 3147. Fax: 207 188 3146. E-mail: william.tong{at}gstt.nhs.uk

{triangledown} Published ahead of print on 23 July 2008.

Journal of Clinical Microbiology, October 2008, p. 3192-3200, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00628-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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