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Journal of Clinical Microbiology, October 2008, p. 3491-3493, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00357-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Association between Hypermutator Phenotype, Clinical Variables, Mucoid Phenotype, and Antimicrobial Resistance in Pseudomonas aeruginosa{triangledown}

David J. Waine,1,2* David Honeybourne,1,2 E. Grace Smith,3 Joanna L. Whitehouse,2 and Chris G. Dowson1

Department of Biological Sciences, Warwick University, Coventry CV4 7AL, United Kingdom,1 West Midlands Adult CF Unit, Heart of England Foundation Trust, Birmingham B9 5SS, United Kingdom,2 Department of Microbiology, Heart of England Foundation Trust, Birmingham B9 5SS, United Kingdom3

Received 21 February 2008/ Returned for modification 29 March 2008/ Accepted 26 July 2008

The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.

* Corresponding author. Mailing address: West Midlands Adult CF Unit, Heart of England Foundation Trust, Birmingham B9 5SS, United Kingdom. Phone: 44(0)121 424 5670. Fax: 44(0)121 424 1661. E-mail: djwaine{at}doctors.org.uk

{triangledown} Published ahead of print on 6 August 2008.

Journal of Clinical Microbiology, October 2008, p. 3491-3493, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00357-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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