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Journal of Clinical Microbiology, November 2008, p. 3639-3645, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00605-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mycobacterium tuberculosis Population Structures Differ Significantly on Two Indonesian Islands{triangledown}

Ida Parwati,1* Reinout van Crevel,2 Mirawati Sudiro,3 Bachti Alisjahbana,4 Trevino Pakasi,5 Kristin Kremer,6 Adri van der Zanden,7 and Dick van Soolingen6

Clinical Pathology Department,1 Internal Medicine Department, Medical Faculty, Padjadjaran University, Bandung,4 Departments of Microbiology,3 Community Medicine, Medical Faculty, University of Indonesia, Jakarta, Indonesia,5 Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen,2 Department of Medical Microbiology, Medisch Spectrum Twente, Enschede,7 Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands6

Received 31 March 2008/ Returned for modification 18 August 2008/ Accepted 7 September 2008

Comparison of Mycobacterium tuberculosis genotype distributions in different areas might help to find determinants of the emergence of certain genotypes, such as the Beijing family. In this study, M. tuberculosis isolates originating from patients from two Indonesian islands were genotyped, and possible associations with patients' characteristics and drug resistance were explored. A high degree of genetic diversity was observed among the M. tuberculosis strains, and a significant difference was found in the geographical distribution of genotype families. The predominant Beijing genotype family was isolated from 268 of 813 patients from West Java (33.0%) versus 12 of 84 patients from Timor (14.3%) (P = 0.002). Family F (East African-Indian) (33.3%) and family D (Latin American and Mediterranean) (20.0%) were more prevalent in Timor. No significant associations were found between genotype families and age, vaccination with Mycobacterium bovis BCG, previous treatment, disease localization, or drug resistance. Possible explanations for the differences in the geographical distribution of the M. tuberculosis genotypes are discussed.

* Corresponding author. Mailing address: Department of Clinical Pathology, Dr. Hasan Sadikin Hospital, Medical Faculty, Padjadjaran University, Bandung, Indonesia. Phone and fax: 62 22 2033307. E-mail: idaparwati2008{at}gmail.com

{triangledown} Published ahead of print on 24 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3639-3645, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00605-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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