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Journal of Clinical Microbiology, November 2008, p. 3788-3790, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01427-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Emergence of Amantadine-Resistant H3N2 Avian Influenza A Virus in South Korea {triangledown}

Jiyeon Lee, Young Jun Song, Jeung Hyun Park, Jun-Han Lee, Yun Hee Baek, Min-Suk Song, Taek-Kyu Oh, Heon-Seok Han, Philippe Noriel Q. Pascua, and Young-Ki Choi*

College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju 361-763, Republic of Korea

Received 25 July 2008/ Returned for modification 7 August 2008/ Accepted 25 August 2008

We found a relatively high frequency of unique amantadine-resistant H3N2 and H9N2 avian influenza viruses (Val27Ile on M2 protein) isolated from live poultry markets in South Korea and confirmed that a Val27Ile single substitution in the M2 protein is enough to acquire the amantadine resistance phenotype by using reverse-genetically created human-avian reassortant viruses.

* Corresponding author. Mailing address: College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju 361-763, Republic of Korea. Phone: 82-43-261-3384. Fax: 82-43-272-1603. E-mail: choiki55{at}chungbuk.ac.kr

{triangledown} Published ahead of print on 24 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3788-3790, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01427-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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