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Journal of Clinical Microbiology, November 2008, p. 3811-3812, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01682-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Cost-Effectiveness of Different Strategies for Amplified Mycobacterium tuberculosis Direct Testing for Cases of Pulmonary Tuberculosis {triangledown}

Renata L. Guerra,1,2 Nancy M. Hooper,3 James F. Baker,3 Roya Alborz,3 Derek T. Armstrong,3 Julia A. Kiehlbauch,3 Marcus B. Conde,2 and Susan E. Dorman1*

Johns Hopkins University School of Medicine, Baltimore, Maryland,1 Instituto de Doenças do Tórax/Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil,2 Maryland State Department of Health and Mental Hygiene, Baltimore, Maryland3

Received 29 August 2008/ Accepted 8 September 2008

We conducted a decision analysis to assess and compare four algorithms for amplified Mycobacterium tuberculosis direct (MTD) testing of respiratory specimens in terms of cost-effectiveness. The most cost-effective strategy was one in which smear-positive specimens but not smear-negative specimens were diluted prior to MTD testing.

* Corresponding author. Mailing address: Johns Hopkins University Center for Tuberculosis Research, 1550 Orleans Street, Room 1M-06, Baltimore, MD 21231. Phone: (410) 502-2717. Fax: (410) 955-0740. E-mail: dsusan1{at}jhmi.edu

{triangledown} Published ahead of print on 17 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3811-3812, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01682-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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