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Journal of Clinical Microbiology, November 2008, p. 3817-3821, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00940-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

High Genetic Diversity of Nontypeable Haemophilus influenzae Isolates from Two Children Attending a Day Care Center{triangledown}

Nathan C. LaCross,1 Carl F. Marrs,1 Mayuri Patel,2 Sara A. Sandstedt,1 and Janet R. Gilsdorf1,2*

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan,1 Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan2

Received 16 May 2008/ Returned for modification 11 July 2008/ Accepted 13 September 2008

Twenty-one nontypeable Haemophilus influenzae (NTHi) isolates from the throats of two healthy children were genotyped by multilocus sequence typing. Nine unique sequence types (STs) were identified. These STs were scattered throughout the phylogenetic tree of reported NTHi STs, demonstrating the high level of NTHi diversity found in colonized children.

* Corresponding author. Mailing address: Department of Pediatrics and Communicable Diseases, L2225 Women's Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0244. Phone: (734) 763-2440. Fax: (734) 936-7635. E-mail: gilsdorf{at}umich.edu

{triangledown} Published ahead of print on 24 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3817-3821, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00940-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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