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Journal of Clinical Microbiology, December 2008, p. 4041-4044, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.01315-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genetic Diversity of Isoniazid-Resistant Mycobacterium tuberculosis Isolates Collected in Poland and Assessed by Spoligotyping{triangledown}

Ewa Augustynowicz-Kopec, Tomasz Jagielski, and Zofia Zwolska*

Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland

Received 11 July 2008/ Returned for modification 2 September 2008/ Accepted 23 September 2008

The genetic compositions of 71 isoniazid-resistant Mycobacterium tuberculosis strains from Poland were determined by spoligotyping. Nearly 80% of the isolates belonged to either the T or the Haarlem family. The genotypic diversity was largely due to variation within those families. The scarcity of imported genotypes suggested that the M. tuberculosis population studied has an endemic nature.

* Corresponding author. Mailing address: National Tuberculosis and Lung Diseases Research Institute, Department of Microbiology, Plocka 26, Warsaw 01-138, Poland. Phone: 48 22 43 12 382. Fax: 48 22 43 12 182. E-mail: z.zwolska{at}igichp.edu.pl

{triangledown} Published ahead of print on 1 October 2008.

Journal of Clinical Microbiology, December 2008, p. 4041-4044, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.01315-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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