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Journal of Clinical Microbiology, February 2008, p. 763-765, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01867-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Microbicide Tenofovir Does Not Inhibit Nucleic Acid Amplification Tests for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Urine Samples{triangledown}

Billie Jo Wood,1 Patricia Rizzo-Price,1 Jeff Holden,1 Andrew Hardick,1 Thomas C. Quinn,1,2 and Charlotte A. Gaydos1*

The Johns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, Maryland,1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland2

Received 19 September 2007/ Returned for modification 5 November 2007/ Accepted 19 November 2007

The potential inhibitory effects of tenofovir and a placebo were examined using the Becton Dickinson ProbeTec, Gen-Probe Aptima Combo 2, and Roche Amplicor tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae. Concentrations of 5% to 0% of tenofovir and the placebo were added to dilutions of C. trachomatis and N. gonorrhoeae. No appreciable inhibition was observed.

* Corresponding author. Present address: 720 Rutland Avenue, 1159 Ross, Baltimore, MD 21205. Phone: (410) 614-0932. Fax: (410) 614-9775. E-mail: cgaydos{at}jhmi.edu

{triangledown} Published ahead of print on 5 December 2007.

Journal of Clinical Microbiology, February 2008, p. 763-765, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01867-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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