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Journal of Clinical Microbiology, March 2008, p. 1132-1136, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.01844-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Bacteremia and Infective Endocarditis Caused by a Non-Daptomycin-Susceptible, Vancomycin-Intermediate, and Methicillin-Resistant Staphylococcus aureus Strain in Taiwan{triangledown}

Yu-Tsung Huang,1,2 Cheng-Hsiang Hsiao,3 Chun-Hsing Liao,1 Chung-Wei Lee,4 and Po-Ren Hsueh2,5*

Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan,1 Departments of Internal Medicine,2 Pathology,3 Radiology,4 Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan5

Received 17 September 2007/ Returned for modification 25 October 2007/ Accepted 3 January 2008

We describe the development of nonsusceptibility to daptomycin and vancomycin during treatment for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia associated with infective endocarditis and probable septic thrombophlebitis in a uremic patient. MRSA bacteremia persisted during glycopeptide and subsequent daptomycin treatment but cleared after 5 days' treatment with linezolid and fusidic acid.

* Corresponding author. Mailing address: Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan. Phone: 886-2-23123456, ext. 5355. Fax: 886-2-23224263. E-mail: hsporen{at}ntu.edu.tw

{triangledown} Published ahead of print on 16 January 2008.

Journal of Clinical Microbiology, March 2008, p. 1132-1136, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.01844-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Warren, R. E. (2008). Daptomycin in endocarditis and bacteraemia: a British perspective. J Antimicrob Chemother 62: iii25-iii33 [Abstract] [Full Text]  


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