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Journal of Clinical Microbiology, April 2008, p. 1470-1473, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02273-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Mucoid Exopolysaccharide Production by Members of the Burkholderia cepacia Complex{triangledown}

James E. A. Zlosnik,1 Trevor J. Hird,1 Monica C. Fraenkel,1 Leonilde M. Moreira,2 Deborah A. Henry,1 and David P. Speert1*

Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia and Child and Family Research Institute, Vancouver, British Columbia, Canada,1 Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal2

Received 23 November 2007/ Returned for modification 15 January 2008/ Accepted 29 January 2008

We demonstrate that all nine species of the Burkholderia cepacia complex can express the mucoid phenotype. A survey of clinical isolates showed that strains of B. cenocepacia, the most virulent species of the complex, are most frequently nonmucoid. Additionally, isolates from patients with chronic infections can convert from mucoid to nonmucoid.

* Corresponding author. Mailing address: Room 377, Child and Family Research Institute, 950 West 28th Ave., Vancouver, BC V5Z 4H4, Canada. Phone: (604) 875-2438. Fax: (604) 875-2226. E-mail: dspeert{at}cw.bc.ca

{triangledown} Published ahead of print on 6 February 2008.

Journal of Clinical Microbiology, April 2008, p. 1470-1473, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02273-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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