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Journal of Clinical Microbiology, May 2008, p. 1780-1784, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.02405-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genotypic Diversity of Coagulase-Negative Staphylococci Causing Endocarditis: a Global Perspective{triangledown}

Cathy A. Petti,1,2* Keith E. Simmon,2 Jose M. Miro,3 Bruno Hoen,4 Francesc Marco,3 Vivian H. Chu,5 Eugene Athan,7 Suzana Bukovski,8 Emilio Bouza,9 Suzanne Bradley,10 Vance G. Fowler,5 Efthymia Giannitsioti,11 David Gordon,12 Porl Reinbott,13 Tony Korman,14 Selwyn Lang,15 Cristina Garcia-de-la-Maria,3 Annibale Raglio,16 Arthur J. Morris,17 Patrick Plesiat,4 Suzanne Ryan,18 Thanh Doco-Lecompte,19 Francesca Tripodi,20 Riccardo Utili,20 Dannah Wray,21 J. Jeffrey Federspiel,5 K. Boisson,4 L. Barth Reller,5 David R. Murdoch,22 Christopher W. Woods,5,6 and the International Collaboration on Endocarditis—Microbiology Investigators

Departments of Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, Utah,1 ARUP Laboratories, Salt Lake City, Utah,2 Hospital Clinic Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain,3 University Medical Center of Besançon, Besançon, France,4 Duke University Medical Center,5 Veterans Administration Medical Center, Durham, North Carolina,6 Barwon Health, Geelong, Australia,7 University Hospital for Infectious Disease, Zagreb, Croatia,8 Hospital General Universitario Gregorio Marañón, Madrid, Spain,9 Veterans Administration Medical Center, Ann Arbor, Michigan,10 Attikon University General Hospital, Athens, Greece,11 Flinders Medical Centre, Adelaide, Australia,12 The University of South Wales, Sydney, Australia,13 Southern Health, Clayton, Australia,14 Middlemore Hospital, Auckland, New Zealand,15 Ospedali Riuniti di Bergamo, Bergamo, Italy,16 Auckland City Hospital, Auckland, New Zealand,17 South Eastern Sydney and Illawarra Area Health Service, Australia,18 CHU Nancy-Brabois, Nancy, France,19 Second University of Naples, Naples, Italy,20 Medical University of South Carolina, Charleston, South Carolina,21 University of Otago, Christchurch, New Zealand,22

Received 16 December 2007/ Returned for modification 26 February 2008/ Accepted 14 March 2008

Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis—Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.

* Corresponding author. Mailing address: University of Utah School of Medicine, ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108. Phone: (801) 583-2787. Fax: (801) 584-5207. E-mail: cathy.petti{at}aruplab.com

{triangledown} Published ahead of print on 26 March 2008.

Journal of Clinical Microbiology, May 2008, p. 1780-1784, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.02405-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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