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Journal of Clinical Microbiology, May 2008, p. 1854-1857, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.00105-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Direct Comparison of the GenoType MTBC and Genomic Deletion Assays in Terms of Ability To Distinguish between Members of the Mycobacterium tuberculosis Complex in Clinical Isolates and in Clinical Specimens{triangledown}

Akos Somoskovi,1 Jillian Dormandy,1 Jeremy Rivenburg,1 Maria Pedrosa,2 Melinda McBride,2 and Max Salfinger1,2*

Wadsworth Center, New York State Department of Health, Albany, New York,1 Bureau of Laboratories, Florida Department of Health, Jacksonville, Florida2

Received 15 January 2007/ Returned for modification 18 March 2007/ Accepted 6 March 2008

The automated GenoType MTBC assay was evaluated for the ability to detect and identify members of the Mycobacterium tuberculosis complex. In addition to 35 reference strains and 157 clinical isolates, performance of this assay was tested directly on 79 smear-positive clinical specimens. The assay proved as accurate as the reference deletion analysis for all 192 isolates and detected and identified M. tuberculosis complex members in 93.2% of the specimens containing the M. tuberculosis complex.

* Corresponding author. Present address: Bureau of Laboratories, Florida Department of Health, 4052 Bald Cypress Way, A-15, Tallahassee, FL 32399-1716. Phone: (850) 245-4517. Fax: (850) 921-9906. E-mail: Max_Salfinger{at}doh.state.fl.us

{triangledown} Published ahead of print on 19 March 2008.

Journal of Clinical Microbiology, May 2008, p. 1854-1857, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.00105-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • de Jong, E., Rentenaar, R. J., van Pelt, R., de Lange, W., Schreurs, W., van Soolingen, D., Sturm, P. D. J. (2009). Two Cases of Mycobacterium microti-Induced Culture-Negative Tuberculosis. J. Clin. Microbiol. 47: 3038-3040 [Abstract] [Full Text]  
  • Pinsky, B. A., Banaei, N. (2008). Multiplex Real-Time PCR Assay for Rapid Identification of Mycobacterium tuberculosis Complex Members to the Species Level. J. Clin. Microbiol. 46: 2241-2246 [Abstract] [Full Text]  


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