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Journal of Clinical Microbiology, June 2008, p. 2083-2087, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00611-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Rapid Differentiation of Methicillin-Susceptible Staphylococcus aureus from Methicillin-Resistant S. aureus and MIC Determinations by Isothermal Microcalorimetry {triangledown}

Ueli von Ah, Dieter Wirz, and A. U. Daniels*

Laboratory for Orthopaedic Biomechanics, Clinical Morphology & Biomedical Engineering, University of Basel Faculty of Medicine, Basel, Switzerland

Received 31 March 2008/ Accepted 10 April 2008

In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h, whereas the standard method required 24 h. The MICs of cefoxitin were successfully determined for MRSA and MSSA by using IMC.

* Corresponding author. Mailing address: LOB, c/o Biozentrum/Pharmazentrum, Klingelbergstr. 50-70, 4056 Basel, Switzerland. Phone: 41 61 265 94 64. Fax: 41 61 265 95 74. E-mail: au.daniels{at}unibas.ch

{triangledown} Published ahead of print on 16 April 2008.

Journal of Clinical Microbiology, June 2008, p. 2083-2087, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00611-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Baldoni, D., Hermann, H., Frei, R., Trampuz, A., Steinhuber, A. (2009). Performance of Microcalorimetry for Early Detection of Methicillin Resistance in Clinical Isolates of Staphylococcus aureus. J. Clin. Microbiol. 47: 774-776 [Abstract] [Full Text]  


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