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Journal of Clinical Microbiology, June 2008, p. 2106-2108, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00345-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Occult Hepatitis C Virus Infection Revisited with Ultrasensitive Real-Time PCR Assay {triangledown}

Philippe Halfon,1* Marc Bourlière,2 Denis Ouzan,3 Damien Sène,4 David Saadoun,4 Hacène Khiri,1 Guillaume Pénaranda,5 Agnes Martineau,1 Valérie Oulès,2 and Patrice Cacoub4

Laboratoire Alphabio, Hôpital Ambroise Paré, Marseille, France,1 Département d'Hépato-Gastroentérologie, Hôpital Saint-Joseph, Marseille, France,2 Département d'Hépato-Gastroentérologie, Institut Arnault Tzanck, Saint-Laurent du Var, France,3 Université Pierre et Marie Curie-Paris 6, CNRS, UMR 7087-AP-HP, Hôpital Pitié-Salpêtrière, Service de Médecine Interne, Paris, France,4 Département Biostatistiques, CDL Pharma, Marseille, France5

Received 19 February 2008/ Returned for modification 2 April 2008/ Accepted 18 April 2008

Occult hepatitis C infection is regarded as a new entity that should be considered when diagnosing patients with a liver disease of unknown origin. Using an ultrasensitive real-time PCR assay, we demonstrated that occult hepatitis C virus (HCV) infection cannot be found in peripheral blood mononuclear cells of patients with cryptogenic liver diseases, HCV-associated systemic vasculitis, or connective tissue diseases. The significance of such occult infection must be elucidated.

* Corresponding author. Mailing address: Laboratoire Alphabio, 23 rue de Friedland, Hôpital Ambroise Paré, 13006 Marseille, France. Phone: (33) 4 91 25 41 00. Fax: (33) 4 91 79 20 44. E-mail: philippe.halfon{at}alphabio.fr

{triangledown} Published ahead of print on 30 April 2008.

Journal of Clinical Microbiology, June 2008, p. 2106-2108, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00345-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Carreno, V., Bartolome, J., Castillo, I., Quiroga, J. A., Halfon, P., Martinot-Peignoux, M., Maylin, S., Bourliere, M., Cacoub, P. (2008). Does Occult Hepatitis C Virus Infection Exist?. J. Clin. Microbiol. 46: 3550-3552 [Full Text]  


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