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Journal of Clinical Microbiology, August 2008, p. 2790-2793, Vol. 46, No. 8
0095-1137/08/$08.00+0     doi:10.1128/JCM.00719-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Association between 16S-23S Internal Transcribed Spacer Sequence Groups of Mycobacterium avium Complex and Pulmonary Disease{triangledown} ,{dagger}

Jason E. Stout,1* Gregory W. Hopkins,2 Jay R. McDonald,3,{ddagger} Anita Quinn,4,§ Carol D. Hamilton,5 L. Barth Reller,6 and Richard Frothingham7

Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina,1 Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina,2 Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina,3 Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina,4 Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina,5 Division of Infectious Diseases and International Health, Department of Medicine, Department of Pathology, Duke University Medical Center, Durham, North Carolina,6 Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina, and Infectious Diseases Section, Veterans Affairs Medical Center, Durham, North Carolina7

Received 15 April 2008/ Accepted 3 June 2008

Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.


* Corresponding author. Mailing address: Box 3306, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-3279. Fax: (919) 681-7494. E-mail: stout002{at}mc.duke.edu

{triangledown} Published ahead of print on 11 June 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

{ddagger} Present address: Department of Medicine, Washington University School of Medicine, St. Louis, MO.

§ Present address: Genomic Services Division, Almac Diagnostics, Durham, NC.


Journal of Clinical Microbiology, August 2008, p. 2790-2793, Vol. 46, No. 8
0095-1137/08/$08.00+0     doi:10.1128/JCM.00719-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.