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Journal of Clinical Microbiology, September 2008, p. 2902-2905, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00937-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Trends in Species Distribution and Susceptibility of Bloodstream Isolates of Candida Collected in Monterrey, Mexico, to Seven Antifungal Agents: Results of a 3-Year (2004 to 2007) Surveillance Study {triangledown}

Gloria M. González,1* Mariana Elizondo,1 and Jacobo Ayala2

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León,1 Unidad de Vigilancia Epidemiológica, Hospital San José-Tec. de Monterrey, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico2

Received 15 May 2008/ Returned for modification 5 June 2008/ Accepted 7 July 2008

During a 3-year surveillance program (2004 to 2007) in Monterrey, Mexico, 398 isolates of Candida spp. were collected from five hospitals. We established the species distribution and in vitro susceptibilities of these isolates. The species included 127 Candida albicans strains, 151 C. parapsilosis strains, 59 C. tropicalis strains, 32 C. glabrata strains, 11 C. krusei strains, 5 C. guilliermondii strains, 4 C. famata strains, 2 C. utilis strains, 2 C. zeylanoides strains, 2 C. rugosa strains, 2 C. lusitaniae strains, and 1 C. boidinii strain. The species distribution differed with the age of the patients. The proportion of candidemias caused by C. parapsilosis was higher among infants ≤1 year old, and the proportion of candidemias caused by C. glabrata increased with patient age (>45 years old). MICs were calculated following the criteria of the Clinical Laboratory Standards Institute reference broth macrodilution method. Overall, C. albicans, C. parapsilosis, and C. tropicalis isolates were susceptible to fluconazole and amphotericin B. However, 31.3% of C. glabrata isolates were resistant to fluconazole (MIC ≥ 64 µg/ml), 43.3% were resistant to itraconazole (MIC ≥ 1 µg/ml), and 12.5% displayed resistance to amphotericin B (MIC ≥ 2 µg/ml). Newer triazoles, namely, voriconazole, posaconazole, and ravuconazole, had a notable in vitro activity against all Candida species tested. Also, caspofungin was active against Candida sp. isolates (MIC90 ≤ 0.5 µg/ml) except C. parapsilosis (MIC90 = 2 µg/ml). It is imperative to promote a national-level surveillance program to monitor this important microorganism.

* Corresponding author. Mailing address: Facultad de Medicina, Universidad Autónoma de Nuevo León, Departamento de Microbiología, Madero y Dr. Eduardo A. Pequeño s/n, Colonia Mitras Centro, Monterrey, NL, México 64460. Phone: (5281) 8329 4166. Fax: (5281) 8348 5477. E-mail: gmglez{at}yahoo.com.mx

{triangledown} Published ahead of print on 16 July 2008.

Journal of Clinical Microbiology, September 2008, p. 2902-2905, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00937-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pfaller, M. A., Messer, S. A., Hollis, R. J., Boyken, L., Tendolkar, S., Kroeger, J., Diekema, D. J. (2009). Variation in Susceptibility of Bloodstream Isolates of Candida glabrata to Fluconazole According to Patient Age and Geographic Location in the United States in 2001 to 2007. J. Clin. Microbiol. 47: 3185-3190 [Abstract] [Full Text]  


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