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Journal of Clinical Microbiology, September 2008, p. 2938-2944, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00232-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Acinetobacter baylyi as a Pathogen for Opportunistic Infection{triangledown}

Te-Li Chen,1,2 Leung-Kei Siu,3 Yi-Tzu Lee,1 Chien-Pei Chen,1 Li-Yueh Huang,3 Roy Chen-Chih Wu,2 Wen-Long Cho,2 and Chang-Phone Fung1,2,4*

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital,1 Institute of Tropical Medicine, School of Medicine, National Yang-Ming University,2 Division of Clinical Research, National Health Research Institutes, Taipei,3 Chutung Veterans Hospital, Chutung, Taiwan4

Received 4 February 2008/ Returned for modification 26 February 2008/ Accepted 3 July 2008

There are no previous reports of human infection due to Acinetobacter baylyi. In this study, we report on six patients with bacteremia due to A. baylyi, based on analysis of the 16S-23S rRNA intergenic spacer and the 16S rRNA gene. All six patients had multiple underlying diseases. The infection was nosocomially acquired in five patients. The six clinical isolates had similar ribopatterns, suggesting a clonal relationship. Compared to the reference strain, the clinical isolates were more resistant to antimicrobial agents, especially beta-lactam antibiotics. In three of the isolates, they may have undetermined plasmid mediated class C type beta-lactamases because of the positive results in a double-disk synergy test using 3-aminophenylboronic acid. Two of the clinical isolates retained a level of natural transformability similar to that of the reference strain. None of the patients died, although only three of them received appropriate antimicrobial therapy. This study demonstrates that A. baylyi is a potential human pathogen that can cause nosocomial infection in immunocompromised patients.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan. Phone: 886 3 596 2134, ext. 101. Fax: 886 3 595 7196. E-mail: cpfung{at}vghtpe.gov.tw

{triangledown} Published ahead of print on 16 July 2008.

Journal of Clinical Microbiology, September 2008, p. 2938-2944, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.00232-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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