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Journal of Clinical Microbiology, September 2008, p. 3073-3076, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.01209-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparative Study of Nasopharyngeal Aspirate and Nasal Swab Specimens for Diagnosis of Acute Viral Respiratory Infection{triangledown}

Rita Y. T. Sung,1* Paul K. S. Chan,2,3 Kai C. Choi,4 Apple C. M. Yeung,2 Albert M. Li,1 Julian W. Tang,2 Margaret Ip,2 Tracy Tsen,1 and E. Anthony S. Nelson1

Departments of Paediatrics,1 Microbiology,2 Stanley Ho Centre for Emerging Infectious Diseases,3 Centre for Epidemiology and Biostatistics, Chinese University of Hong Kong, Hong Kong4

Received 25 June 2008/ Returned for modification 27 June 2008/ Accepted 30 June 2008

Paired nasopharyngeal aspirate (NPA) and nasal swab (NS) samples from 475 children hospitalized for acute respiratory infection were studied for the detection of influenza virus, parainfluenza virus, respiratory syncytial virus, and adenovirus by immunofluorescence test, viral culture, and multiplex PCR assay. The overall sensitivity of viral detection with NPA specimens was higher than that obtained with NS specimens.

* Corresponding author. Mailing address: Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing Street, Shatin, Hong Kong. Phone: 852 26322855. Fax: 852 26360020. E-mail: yntzsung{at}cuhk.edu.hk

{triangledown} Published ahead of print on 9 July 2008.

Journal of Clinical Microbiology, September 2008, p. 3073-3076, Vol. 46, No. 9
0095-1137/08/$08.00+0     doi:10.1128/JCM.01209-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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