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Journal of Clinical Microbiology, January 2009, p. 208-211, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01161-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Ciprofloxacin-Resistant Salmonella enterica Serovar Typhi from Kuwait with Novel Mutations in gyrA and parC Genes {triangledown}

Tzonyo Dimitrov,1 Ali A. Dashti,2 Ossama Albaksami,3 Edet E. Udo,4 Mehrez M. Jadaon,2 and M. John Albert4*

Department of Medical Laboratories, Microbiology Unit,1 Department of Pediatrics, Infectious Diseases Hospital, Andalus, Kuwait,3 Medical Laboratory Sciences, Faculty of Allied Health Science,2 Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait4

Received 19 June 2008/ Returned for modification 26 August 2008/ Accepted 17 October 2008

Blood isolates of Salmonella enterica serovar Typhi from two recently returned Bangladeshi patients in Kuwait were ciprofloxacin resistant, with ciprofloxacin MICs of 12 mg/liter for both isolates. Both isolates had three novel gyrA mutations (55-Leu->Trp, 87-Asp->Ala, and 106-Gln->Arg) and three novel parC mutations (84-Glu->Lys, 106-Trp->Gly, and 128-Tyr->Asp).

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Phone and fax: (965) 2 533-2719. E-mail: john{at}hsc.edu.kw

{triangledown} Published ahead of print on 29 October 2008.

Journal of Clinical Microbiology, January 2009, p. 208-211, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01161-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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