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*Blood and Blood Disorders

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Journal of Clinical Microbiology, January 2009, p. 220-222, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01521-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Qualitative Human Immunodeficiency Virus RNA Analysis of Dried Blood Spots for Diagnosis of Infections in Infants{triangledown}

Ryan J. S. Kerr, Gray Player, Susan A. Fiscus, and Julie A. E. Nelson*

UNC Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

Received 7 August 2008/ Returned for modification 10 October 2008/ Accepted 3 November 2008

The Gen-Probe Aptima human immunodeficiency virus type 1 (HIV-1) RNA assay was adapted for the diagnosis of HIV infection in infants by using dried blood spots. The assay was 99% sensitive (128/129) and 100% specific (162/162). This may prove useful in resource-limited settings, since it precludes the need for a phlebotomist and maintenance of a cold chain.

* Corresponding author. Mailing address: University of North Carolina at Chapel Hill, 11-141 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599. Phone: (919) 843-9252. Fax: (919) 966-3015. E-mail: jnelson{at}med.unc.edu

{triangledown} Published ahead of print on 12 November 2008.

Journal of Clinical Microbiology, January 2009, p. 220-222, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01521-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Lenselink, C. H., de Bie, R. P., van Hamont, D., Bakkers, J. M. J. E., Quint, W. G. V., Massuger, L. F. A. G., Bekkers, R. L. M., Melchers, W. J. G. (2009). Detection and Genotyping of Human Papillomavirus in Self-Obtained Cervicovaginal Samples by Using the FTA Cartridge: New Possibilities for Cervical Cancer Screening. J. Clin. Microbiol. 47: 2564-2570 [Abstract] [Full Text]  


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