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Journal of Clinical Microbiology, January 2009, p. 223-226, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01237-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance {triangledown} ,{dagger}

Susanne Homolka,1 Claudio Köser,2 John Archer,2 Sabine Rüsch-Gerdes,1 and Stefan Niemann1*

Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany,1 Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom2

Received 1 July 2008/ Returned for modification 27 October 2008/ Accepted 11 November 2008

Sequence analysis of 58 multidrug-resistant Mycobacterium tuberculosis complex strains from Germany and 55 susceptible strains from a reference collection comprising major phylogenetic lineages confirmed that variations in Rv2629, 191A/C and 965C/T, are specific for genotypes Beijing and Ghana, respectively, but not involved in the development of rifampin (rifampicin) resistance.

* Corresponding author. Mailing address: Molecular Mycobacteriology Group, National Reference Center for Mycobacteria, Research Center Borstel, Parkallee 1, Borstel, Germany. Phone: 49-4537188762. Fax: 49-4537188311. E-mail: sniemann{at}fz-borstel.de

{triangledown} Published ahead of print on 19 November 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, January 2009, p. 223-226, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01237-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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