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Journal of Clinical Microbiology, January 2009, p. 239-241, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.02123-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Presence of the KPC Carbapenemase Gene in Enterobacteriaceae Causing Bacteremia and Its Correlation with In Vitro Carbapenem Susceptibility{triangledown}

Jonas Marschall,1* Robert J. Tibbetts,2 W. Michael Dunne Jr.,2 Jonathan G. Frye,3 Victoria J. Fraser,1 and David K. Warren1

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri,1 Medical Microbiology, Division of Laboratory Medicine, Washington University School of Medicine, St. Louis, Missouri,2 Bacterial Epidemiology and Antimicrobial Resistance Research Unit, USDA, Agricultural Research Service, Athens, Georgia3

Received 5 November 2008/ Accepted 8 November 2008

During 6 months, we obtained Enterobacteriaceae isolates from patients with gram-negative bacteremia at a 1,250-bed teaching hospital in St. Louis, MO, and compared carbapenem susceptibilities with the presence of blaKPC, a transferable carbapenemase gene. Three (1.2%) out of 243 isolates were blaKPC positive. Ertapenem nonsusceptibility had a low positive predictive value.

* Corresponding author. Mailing address: Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110. Phone: (314) 454-8225. Fax: (314) 454-8294. E-mail: jmarscha{at}im.wustl.edu

{triangledown} Published ahead of print on 19 November 2008.

Journal of Clinical Microbiology, January 2009, p. 239-241, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.02123-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Goldfarb, D., Harvey, S.-B., Jessamine, K., Jessamine, P., Toye, B., Desjardins, M. (2009). Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital Transmission. J. Clin. Microbiol. 47: 1920-1922 [Abstract] [Full Text]  


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