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Journal of Clinical Microbiology, January 2009, p. 249-251, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01651-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Association of Nonsynonymous Substitutions in the Intermediate Region of the vacA Gene of Helicobacter pylori with Gastric Diseases in Taiwan{triangledown}

Shew-Meei Sheu,1 Kuei-Hsiang Hung,1 Bor-Shyang Sheu,2 Hsiao-Bai Yang,4 and Jiunn-Jong Wu1,3*

Institutes of Basic Medical Sciences,1 Departments of Medicine,2 Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng-Kung University, Tainan,3 Department of Pathology, Ton-Yen General Hospital, Hsinchu, Taiwan4

Received 26 August 2008/ Returned for modification 19 October 2008/ Accepted 6 November 2008

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGITSSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the i1-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

* Corresponding author. Mailing address: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, College of Medicine, No. 1, University Road, Tainan 701, Taiwan. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw

{triangledown} Published ahead of print on 19 November 2008.

Journal of Clinical Microbiology, January 2009, p. 249-251, Vol. 47, No. 1
0095-1137/09/$08.00+0     doi:10.1128/JCM.01651-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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