This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xia, S.
Right arrow Articles by Aarestrup, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xia, S.
Right arrow Articles by Aarestrup, F. M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, February 2009, p. 401-409, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01099-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Characterization and Antimicrobial Susceptibility of Salmonella Isolates from Infections in Humans in Henan Province, China{triangledown}

Shengli Xia,1 Rene S. Hendriksen,2 Zhiqiang Xie,1 Lili Huang,1 Jin Zhang,1 Wanshen Guo,1 Bianli Xu,1 Lu Ran,3 and Frank M. Aarestrup2*

Branch for Enteric Disease Control and Prevention, Institute for Infectious Disease Control and Prevention, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China,1 WHO Collaborating Centre for Antimicrobial Resistance in Food-Borne Pathogens and EU Community Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Bülowsvej 27, DK-1790 Copenhagen V, Denmark,2 Branch for Enteric Disease Control and Prevention, Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China3

Received 10 June 2008/ Returned for modification 13 October 2008/ Accepted 1 December 2008

We characterized 208 human Salmonella isolates from 2006 to 2007 and 27 human Salmonella enterica serovar Typhimurium isolates from 1987 to 1993 from Henan Province, China, by serotyping, by antimicrobial susceptibility testing, and, for the most common serovars, by pulsed-field gel electrophoresis (PFGE). The most common serovars among the 2006-2007 isolates were S. enterica serovar Typhimurium (27%), S. enterica serovar Enteritidis (17%), S. enterica serovar Derby (10%), S. enterica serovar Indiana (6%), and S. enterica serovar Litchfield (6%). A high percentage of the isolates were multiple-drug resistant, and 54% were resistant to both nalidixic acid and ciprofloxacin. Of these, 42% were resistant to a high level of ciprofloxacin (MIC > 4 µg/ml), whereas for the remaining isolates, the MICs ranged from 0.125 to 2 µg/ml. Five isolates (2%) were ceftiofur resistant and harbored blaCTX-M14 or blaCTX-M15. With the possible exception of the quinolones and cephalosporins, the 1987-1993 S. enterica serovar Typhimurium isolates were almost as resistant as the recent isolates. PFGE typing of S. enterica serovar Typhimurium showed that the most common cluster predominated over time. Two other clusters have emerged, and another cluster has disappeared.

* Corresponding author. Mailing address: WHO Collaborating Centre for Antimicrobial Resistance in Food-Borne Pathogens and EU Community Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Bülowsvej 27, DK-1790 Copenhagen V, Denmark. Phone: 45 72 34 60 00. Fax: 45 72 34 60 01. E-mail: fmaa{at}food.dtu.dk

{triangledown} Published ahead of print on 10 December 2008.

Journal of Clinical Microbiology, February 2009, p. 401-409, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.01099-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»