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Journal of Clinical Microbiology, February 2009, p. 466-468, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.00892-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vivo and In Vitro Alterations in Influenza A/H3N2 Virus M2 and Hemagglutinin Genes: Effect of Passage in MDCK-SIAT1 Cells and Conventional MDCK Cells{triangledown}

Danjuan Li,1* Reiko Saito,1 Yasushi Suzuki,1 Isamu Sato,2 Hassan Zaraket,1 Clyde Dapat,1 Isolde Ma Caperig-Dapat,1 and Hiroshi Suzuki1

Department of Public Health, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan,1 Yoiko Pediatric Clinic, Niigata, Japan2

Received 8 May 2008/ Returned for modification 18 July 2008/ Accepted 24 November 2008

No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.

* Corresponding author. Mailing address: Department of Public Health, Niigata University, Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Chuo-Ward, Niigata City, Niigata Prefecture 951-8510, Japan. Phone: 81-25-227-2129. Fax: 81-25-227-0765. E-mail: juanharbin2008{at}yahoo.co.jp

{triangledown} Published ahead of print on 17 December 2008.

Journal of Clinical Microbiology, February 2009, p. 466-468, Vol. 47, No. 2
0095-1137/09/$08.00+0     doi:10.1128/JCM.00892-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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