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Journal of Clinical Microbiology, March 2009, p. 774-776, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02374-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Performance of Microcalorimetry for Early Detection of Methicillin Resistance in Clinical Isolates of Staphylococcus aureus{triangledown} ,{dagger}

Daniela Baldoni,1 Heinz Hermann,1 Reno Frei,2 Andrej Trampuz,1,3* and Andrea Steinhuber1

Infectious Diseases Research Laboratory, Department of Biomedicine, University Hospital, Basel, Switzerland,1 Microbiology Laboratory, Laboratory Medicine, University Hospital, Basel, Switzerland,2 Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland3

Received 11 December 2008/ Returned for modification 8 January 2009/ Accepted 13 January 2009

We describe a calorimetric assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA) within 5 h. Microbial heat was calculated in culture with and without cefoxitin. Among 30 genetically distinct clinical isolates, 19/20 MRSA (95%) and 10/10 methicillin-susceptible Staphylococcus aureus (100%) were correctly identified. Microcalorimetry may be useful for rapid MRSA screening.

* Corresponding author. Mailing address: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Phone: 41 61 328 60 59. Fax: 41 61 265 31 98. E-mail: atrampuz{at}uhbs.ch

{triangledown} Published ahead of print on 21 January 2009.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, March 2009, p. 774-776, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02374-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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