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Journal of Clinical Microbiology, March 2009, p. 785-786, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02143-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Specificity of Ertapenem Susceptibility Screening for Detection of Klebsiella pneumoniae Carbapenemases{triangledown}

Shannon E. McGettigan,1 Kathleen Andreacchio,2 and Paul H. Edelstein1,2*

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania,1 Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania2

Received 8 November 2008/ Returned for modification 13 December 2008/ Accepted 7 January 2009

Detection of Klebsiella pneumoniae carbapenemases (KPCs) can be nonspecific, especially when KPCs are uncommon. We determined the positive predictive value and specificity of ertapenem resistance for KPC detection in 2,696 Enterobacteriaceae isolates. The positive predictive value and specificity of ertapenem resistance for KPC detection were 74% and 99.2%, respectively.

* Corresponding author. Mailing address: Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, 4 Gates, 3400 Spruce St., Philadelphia, PA 19104-4283. Phone: (215) 662-6651. Fax: (215) 662-6655. E-mail: phe{at}mail.med.upenn.edu

{triangledown} Published ahead of print on 14 January 2009.

Journal of Clinical Microbiology, March 2009, p. 785-786, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.02143-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Toye, B., Krajden, S., Fuksa, M., Low, D. E., Pillai, D. R. (2009). Carbapenem resistance in Canada. CMAJ 180: 1225-1226 [Full Text]  


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