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Journal of Clinical Microbiology, March 2009, p. 841-844, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01622-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Reversion of Influenza A (H3N2) Virus from Amantadine Resistant to Amantadine Sensitive by Further Reassortment in Japan during the 2006-to-2007 Influenza Season {triangledown} ,{dagger}

Yuki Furuse,* Akira Suzuki, Taro Kamigaki, Midori Shimizu, Naoko Fuji, and Hitoshi Oshitani

Tohoku University Graduate School of Medicine, Sendai, Japan

Received 20 August 2008/ Returned for modification 10 October 2008/ Accepted 16 December 2008

In the 2006-to-2007 influenza season, amantadine-sensitive strains were found among the N-lineage influenza A (H3N2) viruses, which were previously believed to be associated with amantadine resistance. Whole-genome sequencing results indicated that this was due to a further reassortment event.

* Corresponding author. Mailing address: Department of Virology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan. Phone: 81-22-717-8211. Fax: 81-22-717-8212. E-mail: furusey{at}mail.tains.tohoku.ac.jp

{triangledown} Published ahead of print on 24 December 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, March 2009, p. 841-844, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.01622-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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