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Journal of Clinical Microbiology, March 2009, p. 859-861, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.00571-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Failure of Cloxacillin in Treatment of a Patient with Borderline Oxacillin-Resistant Staphylococcus aureus Endocarditis{triangledown}

Stuart Skinner,1,2* Melanie Murray,4 Tom Walus,3 and James A. Karlowsky2,3

Department of Medicine, Division of Infectious Diseases, University of Saskatchewan, Saskatoon, Saskatchewan, Canada,1 Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba,2 Department of Clinical Microbiology, Health Sciences Centre/Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada,3 Department of Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada4

Received 25 March 2008/ Returned for modification 16 October 2008/ Accepted 23 December 2008

Clinical evidence for failure with β-lactam therapy has been lacking for patients with borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections. We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. The isolate also had false-negative thermonuclease and coagulase test results.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, University of Saskatchewan, Saskatoon S7N 0W8, Saskatchewan, Canada. Phone: (306) 655-1777. Fax: (306) 975-0383. E-mail: stuart.skinner{at}saskatoonhealthregion.ca

{triangledown} Published ahead of print on 30 December 2008.

Journal of Clinical Microbiology, March 2009, p. 859-861, Vol. 47, No. 3
0095-1137/09/$08.00+0     doi:10.1128/JCM.00571-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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