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Journal of Clinical Microbiology, April 2009, p. 1209-1211, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.00254-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Nevirapine Resistance in Human Immunodeficiency Virus Type 1-Positive Infants Determined Using Dried Blood Spots Stored for Up to Six Years at Room Temperature{triangledown}

Julie A. E. Nelson,1* Amy M. Loftis,1 Deborah Kamwendo,2 Wafaie W. Fawzi,3 Taha E. Taha,4 Robert L. Goldenberg,5 and Susan A. Fiscus1

UNC Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina,1 UNC Project, Lilongwe, Malawi,2 Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts,3 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland,4 College of Medicine, Drexel University, Philadelphia, Pennsylvania5

Received 5 February 2009/ Accepted 6 February 2009

Dried blood spots that had been stored ambiently for 3 to 6 years lost approximately 1 log10 of human immunodeficiency virus type 1 (HIV-1) RNA, but the majority could still be genotyped for resistance. Nevirapine resistance was found in 7/16 (43.5%) HIV-1-positive HIVNET 024 infants at 4 to 6 weeks, but no resistance was found at other time points.

* Corresponding author. Mailing address: University of North Carolina at Chapel Hill, 11-141 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599. Phone: (919) 843-9252. Fax: (919) 966-3015. E-mail: jnelson{at}med.unc.edu

{triangledown} Published ahead of print on 18 February 2009.

Journal of Clinical Microbiology, April 2009, p. 1209-1211, Vol. 47, No. 4
0095-1137/09/$08.00+0     doi:10.1128/JCM.00254-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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