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Journal of Clinical Microbiology, May 2009, p. 1333-1337, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00096-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pilot Study of Association of Bacteria on Breast Implants with Capsular Contracture{triangledown}

Jose L. Del Pozo,1,2 Nho V. Tran,3 Paul M. Petty,3 Craig H. Johnson,3 Molly F. Walsh,3 Uldis Bite,3 Ricky P. Clay,3 Jayawant N. Mandrekar,4 Kerryl E. Piper,1,2 James M. Steckelberg,2 and Robin Patel1,2,5*

Infectious Diseases Research Laboratory,1 Division of Infectious Diseases, Department of Medicine,2 Division of Plastic Surgery,3 Division of Biostatistics,4 Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota5

Received 16 January 2009/ Returned for modification 5 February 2009/ Accepted 24 February 2009

Capsular contracture is the most common and frustrating complication in women who have undergone breast implantation. Its cause and, accordingly, treatment and prevention remain to be elucidated fully. The aim of this prospective observational pilot study was to test the hypothesis that the presence of bacteria on breast implants is associated with capsular contracture. We prospectively studied consecutive patients who underwent breast implant removal for reasons other than overt infection at the Mayo Clinic from February through September 2008. Removed breast implants were processed using a vortexing/sonication procedure and then subjected to semiquantitative culture. Twenty-seven of the 45 implants collected were removed due to significant capsular contracture, among which 9 (33%) had ≥20 CFU bacteria/10 ml sonicate fluid; 18 were removed for reasons other than significant capsular contracture, among which 1 (5%) had ≥20 CFU/10 ml sonicate fluid (P = 0.034). Propionibacterium species, coagulase-negative staphylococci, and Corynebacterium species were the microorganisms isolated. The results of this study demonstrate that there is a significant association between capsular contracture and the presence of bacteria on the implant. The role of these bacteria in the pathogenesis of capsular contracture deserves further study.

* Corresponding author. Mailing address: Divisions of Clinical Microbiology and Infectious Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Phone: (507) 538-0579. Fax: (507) 284-4272. E-mail: patel.robin{at}mayo.edu

{triangledown} Published ahead of print on 4 March 2009.

Journal of Clinical Microbiology, May 2009, p. 1333-1337, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00096-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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