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Journal of Clinical Microbiology, May 2009, p. 1463-1468, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.02467-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Less-Frequent Fusarium Species of Clinical Interest: Correlation between Morphological and Molecular Identification and Antifungal Susceptibility{triangledown}

Mónica Azor,1,2 Josepa Gené,1,2* Josep Cano,1,2 Palanisamy Manikandan,3 Narendran Venkatapathy,3 and Josep Guarro1,2

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut,1 IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain,2 Department of Microbiology, Aravind Eye Hospital, Coimbatore, Tamilnadu, India3

Received 22 December 2008/ Returned for modification 13 February 2009/ Accepted 16 March 2009

Forty-eight Fusarium isolates morphologically identified as belonging to seven species of clinical interest (i.e., Fusarium chlamydosporum, Fusarium dimerum, Fusarium incarnatum, Fusarium napiforme, Fusarium nygamai, Fusarium proliferatum, and Fusarium sacchari) were characterized molecularly by the analysis of the sequences of the TUB region of the β-tubulin gene. F. chlamydosporum and F. dimerum were the most genetically heterogeneous species. A high degree of correlation between the morphological and molecular identification was shown among the isolates studied. A table with the key morphological features for the identification of these Fusarium species is provided. The antifungal susceptibilities of the Fusarium isolates to 11 antifungal drugs were tested; terbinafine was the most active drug against all the species tested with the exception of F. incarnatum, for which amphotericin B was the most active.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/ Sant Llorenç 21, 43201 Reus, Tarragona, Spain. Phone: 34 977 759359. Fax: 34 977 759322. E-mail: josepa.gene{at}urv.cat

{triangledown} Published ahead of print on 25 March 2009.

Journal of Clinical Microbiology, May 2009, p. 1463-1468, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.02467-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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