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Journal of Clinical Microbiology, May 2009, p. 1591-1595, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00706-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease{triangledown}

Loris Pironi,1 Francesca Bonvicini,2 Paolo Gionchetti,3 Antonia D'Errico,4 Fernando Rizzello,3 Catia Corsini,1 Laura Foroni,5 and Giorgio Gallinella2*

Center for Chronic Intestinal Failure, Department of Internal Medicine and Gastroenterology,1 Division of Microbiology, Department of Clinical and Experimental Medicine,2 Center for Inflammatory Bowel Disease, Department of Internal Medicine and Gastroenterology,3 Division of Pathology, Department of Oncology and Hematology,4 Division of Vascular Surgery, Department of Specialistic Surgical and Anesthesiological Sciences, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy5

Received 14 April 2008/ Returned for modification 21 October 2008/ Accepted 17 February 2009

Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.

* Corresponding author. Mailing address: Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy. Phone: 39 051 4290930. Fax: 39 051 307397. E-mail: giorgio.gallinella{at}unibo.it

{triangledown} Published ahead of print on 11 March 2009.

Journal of Clinical Microbiology, May 2009, p. 1591-1595, Vol. 47, No. 5
0095-1137/09/$08.00+0     doi:10.1128/JCM.00706-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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