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Journal of Clinical Microbiology, June 2009, p. 1902-1905, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.02304-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Correlation of Cefoxitin MICs with the Presence of mecA in Staphylococcus spp.{triangledown}

Jana M. Swenson,1* William B. Brasso,2 Mary Jane Ferraro,3 Dwight J. Hardy,4 Cynthia C. Knapp,5 David Lonsway,1 Sigrid McAllister,1 L. Barth Reller,6 Helio S. Sader,7 Dee Shortridge,8 Robert Skov,9 Melvin P. Weinstein,10 Barbara L. Zimmer,11 and Jean B. Patel1

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 BD Diagnostic Systems, Sparks, Maryland 21152,2 Massachusetts General Hospital, Boston, Massachusetts 02114,3 University of Rochester Medical Center Hospital, Rochester, New York 14642,4 Trek Diagnostic Systems, Cleveland, Ohio 44131,5 Duke University Medical Center, Durham, North Carolina 27710,6 JMI Laboratories, North Liberty, Iowa 52317,7 bioMérieux, Inc., Hazelwood, Missouri 63042,8 Statens Serum Institut, Copenhagen 2300, Denmark,9 Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903,10 Siemens Healthcare Diagnostics MicroScan, West Sacramento, California 95691,11

Received 1 December 2008/ Returned for modification 3 February 2009/ Accepted 26 March 2009

This report describes the results of an 11-laboratory study to determine if a cefoxitin broth microdilution MIC test could predict the presence of mecA in staphylococci. Using breakpoints of ≤4 µg/ml for mecA-negative and ≥6 or 8 µg/ml for mecA-positive isolates, sensitivity and specificity based on mecA or presumed mecA for Staphylococcus aureus at 18 h of incubation were 99.7 to 100% in three cation-adjusted Mueller-Hinton broths tested. For coagulase-negative strains at 24 h of incubation, breakpoints of ≤2 µg/ml for mecA-negative and ≥4 µg/ml for mecA-positive isolates gave sensitivity and specificity of 94 to 99% and 69 to 80%, respectively.

* Corresponding author. Mailing address: Mailstop G08, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-0196. Fax: (404) 639-1381. E-mail: jms1{at}cdc.gov

{triangledown} Published ahead of print on 8 April 2009.

Journal of Clinical Microbiology, June 2009, p. 1902-1905, Vol. 47, No. 6
0095-1137/09/$08.00+0     doi:10.1128/JCM.02304-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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