This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Cortelli, S. C.
Right arrow Articles by Cortelli, J. R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cortelli, S. C.
Right arrow Articles by Cortelli, J. R.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, July 2009, p. 2018-2025, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00338-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Diminished Treatment Response of Periodontally Diseased Patients Infected with the JP2 Clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans{triangledown}

Sheila Cavalca Cortelli,1* Fernando Oliveira Costa,2 Toshihisa Kawai,3 Davi Romeiro Aquino,1 Gilson Cesar Nobre Franco,4 Kazuhisa Ohara,3 Caio Vinícius Gonçalves Roman-Torres,1 and José Roberto Cortelli1

Department of Periodontology, Dental Research Division, University of Taubaté, Taubaté, SP, Brazil,1 Department of Periodontology, Dental Research Division, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil,2 Department of Immunology, Forsyth Institute, Boston, Massachusetts,3 Department of Oral Biology, Dental Research Division, University of Taubaté, Taubaté, SP, Brazil4

Received 15 February 2009/ Returned for modification 6 May 2009/ Accepted 13 May 2009

This longitudinal study evaluated the response to periodontal treatment by subjects infected with either JP2 (n = 25) or non-JP2 (n = 25) Aggregatibacter (Actinobacillus) actinomycetemcomitans. Participants were treated during the first 4 months by receiving (i) scaling and root planing, (ii) systemic antibiotic therapy, and (iii) periodontal surgery. Probing depth (PD), clinical attachment level (CAL), and gingival and plaque indices (GI and PI, respectively) were monitored at baseline and at 12 months, along with DNA-PCR-based subgingival detection of JP2 or non-JP2 A. actinomycetemcomitans. At baseline, PD, CAL, and GI scores were statistically higher in the JP2 strain-positive group than the non-JP2-strain-positive group. At 12 months, PD, CAL, and GI scores had decreased significantly for both groups, but the reduction rates of PD and CAL were higher in the non-JP2-strain-positive group. Among JP2-strain-positive patients in the baseline, patients who remained JP2 strain positive at 12 months showed significantly higher GIs than did the patients who had lost the detectable JP2 clone. Patients who remained JP2 strain positive at 12 months appeared to be more resistant to mechanical-chemical therapy than did those who were still non-JP2 strain positive, while the elimination of JP2 A. actinomycetemcomitans remarkably diminished gingival inflammation. Early identification and elimination of the JP2 clone of A. actinomycetemcomitans will enable practitioners to effectively predict the outcome of treatments applied to periodontal patients.

* Corresponding author. Mailing address: Rua Professor Nelson Freire Campelo, 343-Jardim Eulália, Taubaté, São Paulo, Brazil 12010-700. Phone: 55 12 36312373. Fax: 55 12 36322947. E-mail: cavalcacortelli{at}uol.com.br

{triangledown} Published ahead of print on 6 May 2009.

Journal of Clinical Microbiology, July 2009, p. 2018-2025, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00338-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»