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Journal of Clinical Microbiology, July 2009, p. 2317-2320, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00028-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Anomalous Quantitation Standard Growth Curves in a Laboratory-Developed Hepatitis C Virus (HCV) RNA Quantification Assay Using the TaqMan HCV Analyte-Specific Reagent{triangledown}

Jeffrey J. Germer, Jemee D. Kathrotiya, Carrie F. Bouse, P. Shawn Mitchell, and Joseph D. C. Yao*

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905

Received 6 January 2009/ Returned for modification 14 March 2009/ Accepted 26 April 2009

A retrospective examination of quantitation standard growth curves associated with 1,000 unique clinical serum specimens tested by a laboratory-developed TaqMan hepatitis C virus analyte-specific reagent-based assay revealed anomalous growth curves associated with 0.40% (95% confidence interval, 0.11% to 1.00%) of these specimens.

* Corresponding author. Mailing address: Division of Clinical Microbiology, Mayo Clinic, Su 1-602, 200 First Street SW, Rochester, MN 55905-0002. Phone: (507) 538-1934. Fax: (507) 266-4341. E-mail: jdcyao{at}mayo.edu

{triangledown} Published ahead of print on 6 May 2009.

Journal of Clinical Microbiology, July 2009, p. 2317-2320, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00028-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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