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Journal of Clinical Microbiology, July 2009, p. 2328-2331, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00457-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient{triangledown}

Christoph Schoen,1 Christian Unzicker,2 Gernot Stuhler,2 Johannes Elias,1 Hermann Einsele,2 Götz Ulrich Grigoleit,2 Marianne Abele-Horn,1* and Stephan Mielke2

Institute for Hygiene and Microbiology, Julius Maximilian University, Würzburg, Germany,1 Allogeneic Stem Cell Transplant Center, Division of Hematology and Oncology Department of Internal Medicine II, Julius Maximilian University, Würzburg, Germany2

Received 4 March 2009/ Returned for modification 7 April 2009/ Accepted 24 April 2009

Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic patient undergoing cord blood transplantation for secondary acute myeloid leukemia.

* Corresponding author. Mailing address: Institute for Hygiene and Microbiology, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Phone: 49 931 201 46941. Fax: 49 931 201 46445. E-mail: mhorn{at}hygiene.uni-wuerzburg.de

{triangledown} Published ahead of print on 6 May 2009.

Journal of Clinical Microbiology, July 2009, p. 2328-2331, Vol. 47, No. 7
0095-1137/09/$08.00+0     doi:10.1128/JCM.00457-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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