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J. Clin. Microbiol. doi:10.1128/JCM.00828-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Large Sequence Polymorphisms Classify Mycobacterium tuberculosis with Ancestral Spoligotyping Patterns

Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California, San Francisco, CA, USA, Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Centre, Stanford, CA, USA, Tuberculosis Research Center, Chennai, India, School of Medicine, University of California, Davis, CA, USA, Institute for Systems Biology, Seattle, WA, USA

^* To whom correspondence should be addressed. Email: sgagneux{at}systemsbiology.org.

	Abstract

Genomic deletion analysis revealed that strains of Mycobacterium tuberculosis exhibiting spoligotyping patterns with almost all spacers present belong either to a strain lineage that includes the W-Beijing strain family, or to the ancestral strain lineage of M. tuberculosis.

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