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J. Clin. Microbiol. doi:10.1128/JCM.01188-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: impact on laboratory diagnosis

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea, Microbiology and Immunology, The University of Western Australia, Perth, Western Australia, and Department of Laboratory Medicine, Chungnam National University, College of Medicine, Daejeon, Korea

^* To whom correspondence should be addressed. Email: leekcp{at}yumc.yonsei.ac.kr.

	Abstract

Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive, but 21.4% were toxin A negative (A^-B⁺). Binary toxin gene was detected in nine isolates. Higher fluoroquinolone resistance of A^-B⁺ strains may contribute to increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.