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J. Clin. Microbiol. doi:10.1128/JCM.01217-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

MOLECULAR CHARACTERISTICS OF THE M. TUBERCULOSIS LAM-RUS FAMILY PREVALENT IN CENTRAL RUSSIA

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya, Moscow 117997, Russia and State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region, Russia

^* To whom correspondence should be addressed. Email: lana{at}ibch.ru.

	Abstract

We analyzed IS6110-associated polymorphisms in the phospholipase C genes of 107 isolates of Mycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority LAM family strains contained an insertion in a unique position in the plcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate LAM-RUS.