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J. Clin. Microbiol. doi:10.1128/JCM.01305-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A Pilot Study of a Commercialized Human Papillomavirus (HPV) Genotyping Assay: Comparison of HPV Risk Group to Cytology and Histology

Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA; Roche Molecular Systems, Alameda, CA, USA; University of Arizona Health Sciences Center, Tucson, AZ, USA; Medical University of South Carolina, Charleston, SC, USA
Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA; Roche Molecular Systems, Alameda, CA, USA; University of Arizona Health Sciences Center, Tucson, AZ, USA; Medical University of South Carolina, Charleston, SC, USA

	Abstract

We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes using a sample of liquid cytology specimens (n = 534). We found a strong association with HPV risk group (HPV16 > HPV18 > other carcinogenic types > non-carcinogenic types > negative) with increasing severity of cytologic interpretations (P_Trend <0.0005) and histologic diagnoses (P_Trend < 0.0005).

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