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J. Clin. Microbiol. doi:10.1128/JCM.01735-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Novel varicella-zoster virus glycoprotein E gene mutations associated with genotypes A and D

Institute of Medical Virology, Hospital of the Johann Wolfgang Goethe University, D-60596 Frankfurt am Main, Germany; Bernhard-Nocht-Institute for Tropical Medicine, Clinical Virology Laboratory, D-20359 Hamburg, Germany; Department of Dermatology and Venereology, University of Rostock, D-18055 Rostock, Germany; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute for Novel and Emerging Infectious Diseases D-17493 Greifswald, Germany

^* To whom correspondence should be addressed. Email: jonassi{at}gmx.de.

	Abstract

Here we describe the association of certain varicella-zoster virus (VZV) genotypes with unique glycoprotein E (gE) gene mutations. Within 45 analyzed VZV wild-type strains of genotypes A and D five novel gE mutations were discovered. A significant (p < 0.0001) association of certain gE mutations with VZV genotype D was found.

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