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J. Clin. Microbiol. doi:10.1128/JCM.02065-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A major uropathogenic Escherichia coli strain identified in the North West of England by multilocus sequence typing

Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building, Manchester Royal Infirmary, Manchester, M13 9WL, United Kingdom; Preston Microbiology Services, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, Lancs, PR2 9HT, United Kingdom; Health Protection Agency North West Laboratory, Clinical Science Building, Manchester Royal Infirmary, Manchester, M13 9WZ, United Kingdom; Escherichia, Shigella, Yersinia & Vibrio Reference Unit, Laboratory of Enteric Pathogens, Centre for Infections, 61 Colindale Avenue, London, NW9 5HT, United Kingdom

^* To whom correspondence should be addressed. Email: m.upton{at}manchester.ac.uk.

	Abstract

A total of 88 uropathogenic Escherichia coli isolates including 68 isolates from urine and 20 isolates from blood were characterised by Multi-Locus Sequence Typing (MLST). MLST has identified an important genetic lineage of E. coli designated sequence type (ST) – 131, representing 52 of these isolates, 51 of which were resistant to third generation cephalosporins. ST-131 appears to be a drug resistant, uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteraemia and is widely disseminated in both community and hospital patients from different geographical areas in the North West of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli. The portability of MLST allows the accurate monitoring of this antibiotic resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.