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JCM Accepts, published online ahead of print on 6 February 2008
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J. Clin. Microbiol. doi:10.1128/JCM.02273-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex

James E. A. Zlosnik, Trevor J. Hird, Monica C. Fraenkel, Leonilde M. Moreira, Deborah A. Henry, and David P. Speert*

Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia and Child and Family Research Institute, Vancouver, British Columbia, Canada; Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

* To whom correspondence should be addressed. Email: dspeert{at}cw.bc.ca.


   Abstract

We demonstrate that all nine species of the Burkholderia cepacia complex can grow as the mucoid phenotype. A survey of clinical isolates showed that B. cenocepacia, the most virulent species of the complex are most frequently nonmucoid. Additionally, isolates from patients with chronic infections can convert from mucoid to nonmucoid.




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