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J. Clin. Microbiol. doi:10.1128/JCM.02329-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

What is the Optimum Diagnostic Assay and Clinical Specimen for Routine Rotavirus Surveillance?

Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA; Atlanta Research and Education Foundation, Decatur GA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH

^* To whom correspondence should be addressed. Email: Lstockman{at}cdc.gov.

	Abstract

Detection of rotavirus by diagnostic assay and specimen type was compared. In bulk stools, detection rates by reverse-transcriptase polymerase chain reaction (RT-PCR) and by enzyme immunoassay (EIA) were similar but 18% of healthy controls were positive by RT-PCR. Testing bulk stools by EIA appears to be optimum for rotavirus surveillance.