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Journal of Clinical Microbiology
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Research Article

Efficacy of enzyme-linked immunosorbent assay for rapid diagnosis of Bordetella pertussis infection.

A J Lawrence, J C Paton
A J Lawrence
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J C Paton
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ABSTRACT

We examined the diagnostic efficacy of an enzyme-linked immunosorbent assay (ELISA) for class-specific antibodies to Bordetella pertussis in acute-phase sera collected from 1,240 patients with suspected pertussis. A total of 833 serum specimens (67%) yielded positive results. The proportion of positive results increased to 77% if a second (convalescent-phase) serum was also tested. By comparison, a bacterial agglutination test for B. pertussis antibodies was positive in only 21% of acute-phase specimens and 50% of paired specimens. The high proportion of acute-phase sera which were ELISA positive indicates that a measurable serologic response has usually occurred by the time the diagnosis is suspected. Thus, the ELISA is potentially the most rapid means of laboratory confirmation of B. pertussis infection.

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Efficacy of enzyme-linked immunosorbent assay for rapid diagnosis of Bordetella pertussis infection.
A J Lawrence, J C Paton
Journal of Clinical Microbiology Nov 1987, 25 (11) 2102-2104; DOI:

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Efficacy of enzyme-linked immunosorbent assay for rapid diagnosis of Bordetella pertussis infection.
A J Lawrence, J C Paton
Journal of Clinical Microbiology Nov 1987, 25 (11) 2102-2104; DOI:
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